GHK-Cu

Scientific Background & Mechanism

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide. In laboratory research, it is used to investigate cellular signaling pathways involved in extracellular matrix biology, tissue remodeling, and wound-healing processes. Studies have examined its interactions with gene expression, inflammatory signaling, and collagen-related pathways, making it a widely studied research peptide in regenerative biology.

Research Applications

GHK-Cu was first identified in human plasma and has since been detected in saliva and urine. Scientific research has explored its role in biological processes including:

Extracellular matrix remodeling
Collagen and elastin-related pathways
Cellular repair mechanisms
Inflammatory signaling
Gene expression associated with tissue maintenance

Because of these properties, GHK-Cu continues to be investigated in laboratory studies related to regenerative biology, biomaterials, and cellular physiology.

Laboratory Reconstitution Reference

Suggested Reconstitution: 2 mL Bacteriostatic Water (adjust if your laboratory protocol differs)

Storage

Store the lyophilized peptide in a cool, dry place, protected from light and moisture.
For long-term laboratory storage, keep at -20°C or below.
After reconstitution, store refrigerated at 2–8°C.
Avoid repeated freeze-thaw cycles.
Handle using appropriate laboratory procedures to minimize contamination.

Scientific References

Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences. 2018;19(7):1987. doi:10.3390/ijms19071987.
Maquart FX, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex GHK-Cu. FEBS Letters. 1988.
Pickart L. Research describing the biological activity of GHK-Cu in tissue remodeling and extracellular matrix biology.
Research Use Notice

For laboratory research use only. This product is supplied exclusively for scientific and laboratory research. It is not intended for human or animal use. The information provided is for educational and research purposes only and should not be interpreted as medical, veterinary, or clinical guidance.